Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: INPP5D All Species: 11.82
Human Site: S294 Identified Species: 26
UniProt: Q92835 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92835 NP_001017915.1 1189 133292 S294 P E S P H R P S L I P P V T F
Chimpanzee Pan troglodytes XP_526066 929 104074 S62 Q L K V D V E S G K L I I K K
Rhesus Macaque Macaca mulatta XP_001114794 1258 138636 V314 I P V Q A F E V K L D V T L G
Dog Lupus familis XP_542327 1264 138869 V320 V P V Q A F E V K L D V T L G
Cat Felis silvestris
Mouse Mus musculus Q9ES52 1191 133524 S297 S E S T N R R S L I P P V T F
Rat Rattus norvegicus P97573 1190 133575 S296 S E S T N R R S L I P P V T F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520934 1019 113512 V152 A S D S S R G V E S G K L S I
Chicken Gallus gallus XP_422567 1182 133482 S293 P D S T H R R S L I P P V T F
Frog Xenopus laevis Q6P4S2 1019 115278 L152 A P A A N A S L L L S E T L L
Zebra Danio Brachydanio rerio Q2I6J1 1266 140353 L300 V Q T F E V K L D V Y L A D L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789838 1327 148052 I293 R D L P T R N I L P T P F E V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 77.8 41.3 40.9 N.A. 87.8 87.8 N.A. 38.7 68.2 56.5 43.1 N.A. N.A. N.A. N.A. 31
Protein Similarity: 100 77.8 57.5 56.8 N.A. 92.1 92 N.A. 48.5 78.7 67.1 57.9 N.A. N.A. N.A. N.A. 47.3
P-Site Identity: 100 6.6 0 0 N.A. 73.3 73.3 N.A. 6.6 80 6.6 0 N.A. N.A. N.A. N.A. 26.6
P-Site Similarity: 100 13.3 6.6 6.6 N.A. 80 80 N.A. 20 86.6 26.6 20 N.A. N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 0 10 10 19 10 0 0 0 0 0 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 19 10 0 10 0 0 0 10 0 19 0 0 10 0 % D
% Glu: 0 28 0 0 10 0 28 0 10 0 0 10 0 10 0 % E
% Phe: 0 0 0 10 0 19 0 0 0 0 0 0 10 0 37 % F
% Gly: 0 0 0 0 0 0 10 0 10 0 10 0 0 0 19 % G
% His: 0 0 0 0 19 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 0 0 10 0 37 0 10 10 0 10 % I
% Lys: 0 0 10 0 0 0 10 0 19 10 0 10 0 10 10 % K
% Leu: 0 10 10 0 0 0 0 19 55 28 10 10 10 28 19 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 28 0 10 0 0 0 0 0 0 0 0 % N
% Pro: 19 28 0 19 0 0 10 0 0 10 37 46 0 0 0 % P
% Gln: 10 10 0 19 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 10 0 0 0 0 55 28 0 0 0 0 0 0 0 0 % R
% Ser: 19 10 37 10 10 0 10 46 0 10 10 0 0 10 0 % S
% Thr: 0 0 10 28 10 0 0 0 0 0 10 0 28 37 0 % T
% Val: 19 0 19 10 0 19 0 28 0 10 0 19 37 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _